LIM domain proteins in cell mechanobiology
نویسندگان
چکیده
منابع مشابه
Single-stranded DNA-binding proteins regulate the abundance of LIM domain and LIM domain-binding proteins.
The LIM domain-binding protein Ldb1 is an essential cofactor of LIM-homeodomain (LIM-HD) and LIM-only (LMO) proteins in development. The stoichiometry of Ldb1, LIM-HD, and LMO proteins is tightly controlled in the cell and is likely a critical determinant of their biological actions. Single-stranded DNA-binding proteins (SSBPs) were recently shown to interact with Ldb1 and are also important in...
متن کاملALP/Enigma PDZ-LIM domain proteins in the heart.
Actinin-associated LIM protein (ALP) and Enigma are two subfamilies of Postsynaptic density 95, discs large and zonula occludens-1 (PDZ)-Lin-11, Isl1 and Mec-3 (LIM) domain containing proteins. ALP family members have one PDZ and one LIM domain, whereas Enigma proteins contain one PDZ and three LIM domains. Four ALP and three Enigma proteins have been identified in mammals, each having multiple...
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Diverse new and stimulating results at the interfaces between cell and molecular biology and biophysics were presented in this session cochaired by Ewa Paluch (University College London) and Dennis Discher (University of Pennsylvania). A number of physical features of the cell and its microenvironment were shown to impact the functions and fates of diverse cell types. Five talks of standard len...
متن کاملStem cell mechanobiology.
Stem cells are undifferentiated cells that are capable of proliferation, self-maintenance and differentiation towards specific cell phenotypes. These processes are controlled by a variety of cues including physicochemical factors associated with the specific mechanical environment in which the cells reside. The control of stem cell biology through mechanical factors remains poorly understood an...
متن کاملTwo muscle-specific LIM proteins in Drosophila
The LIM domain defines a zinc-binding motif found in a growing number of eukaryotic proteins that regulate cell growth and differentiation during development. Members of the cysteine-rich protein (CRP) family of LIM proteins have been implicated in muscle differentiation in vertebrates. Here we report the identification and characterization of cDNA clones encoding two members of the CRP family ...
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ژورنال
عنوان ژورنال: Cytoskeleton
سال: 2021
ISSN: 1949-3584,1949-3592
DOI: 10.1002/cm.21677